Apostle Portal for Cancer Genomics
Apostle Cancer Portal is a component of Apostle TRITON™ framework, designed to organize, visualize, and analyze large-scale cancer genomic data.
The Cancer Genome Atlas (TCGA) is a collaboration between the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) that has generated comprehensive, multi-dimensional maps of the key genomic changes in 33 types of cancer. The data provide pan-cancer gene expression profles (RNA-Seq). (12,407 samples)
The Cancer Cell Line Encyclopedia (CCLE) project is an effort to conduct a detailed genetic characterization of a large panel of human cancer cell lines. The CCLE provides public access analysis and visualization of DNA copy number, mRNA expression, mutation data and more, for 1000 cancer cell lines. (1,019 samples)
METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) is a Canada-UK project that aims to classify breast tumors into further subcategories, based on molecular signatures that will help determine the optimal course of treatment. (2,509 samples)
Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT), is a hybridization capture-based next-generation sequencing assay for targeted deep sequencing of all exons and selected introns of 341 key cancer genes in formalin-fixed, paraffin-embedded tumors. The project complied tumor and matched normal sequence data from more than 10,000 patients with advanced cancer. (10,945 samples)
TCGA (Pan-lung cancer)
TCGA pan-lung cancer project; utilizing exome sequences and copy number profiles of 1,144 lung cancers to explore similarities and differences between lung adenocarcinoma and lung squamous cell carcinoma. Consistent with studies of gene expression11, this comparison showed that both mutated genes and recurrent SCNAs are largely distinct between the two lung cancer types. (1,144 samples)